• Initiatives
    • OB Emergency Readiness
    • TeamBirth
    • OMNO
    • Maternal Morbidity and Mortality
    • Low Dose Aspirin
    • Infant Mortality
    • Newborn Screening
    • Therapeutic Hypothermia
    • Hospital Recognition
    • Completed Initiatives
  • Professionals
    • Resources
    • OPNF
    • Legislation
  • Patients
    • Resources
    • Lived Experience Program
    • Map Directory
  • About
    • Faculty and Staff
    • Contact Us
  • Events
  • What’s New
    • Subscribe to our Newsletter
    • Newsletter Archives

Study in Pediatrics: Prenatal Exposure to Acetaminophen and Risk of ADHD

Study in Pediatrics: Prenatal Exposure to Acetaminophen and Risk of ADHD

Category: AAPTags: acetaminophen, adhd, prenatal
November 28, 2017

OBJECTIVES: To estimate the association between maternal use of acetaminophen during pregnancy and of paternal use before pregnancy with attention-deficit/hyperactivity disorder (ADHD) in offspring while adjusting for familial risk for ADHD and indications of acetaminophen use.

METHODS: Diagnoses were obtained from the Norwegian Patient Registry for 112 973 offspring from the Norwegian Mother and Child Cohort Study, including 2246 with ADHD. We estimated hazard ratios (HRs) for an ADHD diagnosis by using Cox proportional hazard models.

RESULTS: After adjusting for maternal use of acetaminophen before pregnancy, familial risk for ADHD, and indications of acetaminophen use, we observed a modest association between any prenatal maternal use of acetaminophen in 1 (HR = 1.07; 95% confidence interval [CI] 0.96–1.19), 2 (HR = 1.22; 95% CI 1.07–1.38), and 3 trimesters (HR = 1.27; 95% CI 0.99–1.63). The HR for more than 29 days of maternal acetaminophen use was 2.20 (95% CI 1.50–3.24). Use for <8 days was negatively associated with ADHD (HR = 0.90; 95% CI 0.81–1.00). Acetaminophen use for fever and infections for 22 to 28 days was associated with ADHD (HR = 6.15; 95% CI 1.71–22.05). Paternal and maternal use of acetaminophen were similarly associated with ADHD.

CONCLUSIONS: Short-term maternal use of acetaminophen during pregnancy was negatively associated with ADHD in offspring. Long-term maternal use of acetaminophen during pregnancy was substantially associated with ADHD even after adjusting for indications of use, familial risk of ADHD, and other potential confounders.

Reference: Eivind Ystrom, Kristin Gustavson, Ragnhild Eek Brandlistuen, Gun Peggy Knudsen, Per Magnus, Ezra Susser, George Davey Smith, Camilla Stoltenberg, Pål Surén, Siri E. Håberg, Mady Hornig, W. Ian Lipkin, Hedvig Nordeng, Ted Reichborn-Kjennerud.
Prenatal Exposure to Acetaminophen and Risk of ADHD.
Pediatrics. Nov 2017, 140 (5) e20163840; DOI: 10.1542/peds.2016-3840

Post navigation

PreviousNext

Recent Posts

  • 2023 AHA and AAP Focused Update on Neonatal Resuscitation Guidelines
  • AAP: Umbilical Cord Milking Versus Delayed Cord Clamping in Infants 28 to 32 Weeks: A Randomized Trial 
  • Newborn Screening Tip of the Month: Unsatisfactory Specimens Newborn
  • Pediatrics Commentary: Further Insights into Cord Management
  • NVSS Vital Statistics Rapid Release: Infant Mortality in the United States: Provisional Data from the 2022 Period Linked Birth/Infant Death File
405 271 7777
920 Stanton L Young Blvd
G. Rainey Williams Pavilion
room WP-2230
Oklahoma City, OK 73104
  • Patients
    • Patient Resources
    • Lived Experience
    • Resource Map
    • OPQIC Initiatives
  • Professionals
    • What's New
    • Resources
    • OPNF
  • Initiatives
    • TeamBirth
    • ED OB Readiness
    • OMNO
    • Infant Mortality
  • About
    • Contact Us
    • Subscribe
Sign up for our monthly newsletter
Sitemap | © 2014-2023 Oklahoma Perinatal Quality Improvement Collaborative. All Rights Reserved.