ACOG Article: Association of Antenatal Depression Symptoms and Antidepressant Treatment With Preterm Birth

Kartik K. Venkatesh, MD, PhD, Laura Riley, MD, Victor M. Castro, MS, Roy H. Perlis, MD, MSc,
and Anjali J. Kaimal, MD, MAS
OBJECTIVE: To evaluate the association of antenatal depression symptoms with preterm birth and small for gestational age (SGA).
METHODS: This was an observational cohort study conducted among women who completed Edinburgh Postnatal Depression Scale screening and delivered at 20 weeks of gestation or greater. The primary outcomes were preterm birth and an SGA neonate at birth (less than 10th percentile for gestational age); the primary predictor was an Edinburgh Postnatal Depression Scale antepartum score of 10 or greater, indicating symptoms of depression. Logistic regression models were used with
and without consideration of antidepressant exposure during pregnancy.