Considerations for the Implementation of Point of Care Tests for Syphilis (hhs.gov)

DISCLAIMER
This document is developed by the National Syphilis and Congenital Syphilis Syndemic Federal Task Force for theImplementation of Point of Care Tests for Syphilis document which is designed to address the challenges in diagnosisand treatment of syphilis. It emphasizes the often-asymptomatic nature of the infection and discusses theimplementation of Point of Care (POC) tests to facilitate rapid diagnosis and treatment during the same visit.

Purpose of the NSCSS Considerations for the Implementation of Point of Care Tests for Syphilis
POC tests for syphilis differs from the traditional laboratory-based serologic testing primarily in specimen collection, time to result, need for confirmation, and sensitivity/specificity. While POC tests offers rapid results using whole blood from a fingerstick, it lacks the comprehensive assessment provided by laboratory-based tests, requiring confirmation and follow-up. It also underscores that laboratory-based testing remains the preferred option, particularly for individuals with a history of syphilis and low-risk individuals. Despite lower sensitivity and specificity, POC tests can be valuable,
especially in settings with high incidence rates or where access to healthcare is limited.